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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, including the recruitment and consent process as well as adherence to the use of commonly available equipment.
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While Pragmatic Play is known for its slot machines, it also provides table games like Bitcoin baccarat and Roulette. They offer more than a dozen licensed games, and their software has a reputation for being secure and reliable. Their products are available across multiple languages and include a variety of betting options including live dealer tables.
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The company's latest release Gates of Olympus takes players to the world of the ancient Greek gods and goddesses, where Zeus supervises the action. This high-volatility game features a Pay Anywhere feature that rewards players with wins when they hit eight or more matching symbols on the reels. This game also comes with the Free Spins bonus with multipliers up to 500x your bet.
A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic Play is a relatively new player in the online casino industry however, it has already established itself through its mobile-friendly slot machines. Their games are optimized for mobile devices and run on HTML5 technology. They are also certified by trusted gaming authorities to ensure fairness and transparency. This is a good indicator for players, since it means that the games are tested and verified to ensure that the results of each round are random and unbiased.
Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. The company is licensed and regulated by a variety of governing bodies which include the Malta Gaming Authority and UK Gambling Commission. Its games are backed by high-end encryption and the security team is available to assist players resolve any issues they might have.
The majority of Pragmatic Play slot games feature traditional themes and modern graphics, which makes them popular for both new and experienced players. Many of them offer progressive jackpots and have multiple paylines and bonus rounds. They are not volatile, which means you can have a long gaming experience.
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Legality
Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. The software is available on mobile devices as well as in various languages. It has established itself as one of the top gaming platforms for casinos despite its relative youth. Wolves is one of the latest games that is a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace explanation studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study which includes the recruitment, design, and delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.